Cocaine can generate a stronger conditioned reinforcer than food despite being a weaker primary reinforcer

BJ Tunstall, DN Kearns - Addiction biology, 2016 - Wiley Online Library
The present study aimed to test the hypothesis that cues associated with drug‐taking
behavior become extra strong motivators of behavior compared with cues paired with non …

A cocaine cue acts as an incentive stimulus in some but not others: implications for addiction

BT Saunders, TE Robinson - Biological psychiatry, 2010 - Elsevier
BACKGROUND: In addicts drug cues attract attention, elicit approach, and motivate drug-
seeking and drug-taking behavior, and addicts find it difficult to resist such cues. In …

[HTML][HTML] Individual variation in the motivational properties of cocaine

BT Saunders, TE Robinson - Neuropsychopharmacology, 2011 - nature.com
Cues in the environment associated with drug use draw the attention of addicts, elicit
approach, and motivate drug-seeking and drug-taking behavior, making abstinence difficult …

A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue

LM Yager, TE Robinson - Psychopharmacology, 2013 - Springer
Rationale Cues associated with rewards bias attention towards them and can motivate drug-
seeking and drug-taking behavior. There is, however, considerable individual variation in …

Impact of repeated intravenous cocaine administration on incentive motivation depends on mode of drug delivery

KH LeBlanc, NT Maidment, SB Ostlund - Addiction biology, 2014 - Wiley Online Library
The incentive sensitization theory of addiction posits that repeated exposure to drugs of
abuse, like cocaine, can lead to long‐term adaptations in the neural circuits that support …

Cue-evoked cocaine “craving”: role of dopamine in the accumbens core

BT Saunders, LM Yager, TE Robinson - Journal of Neuroscience, 2013 - Soc Neuroscience
Drug-associated cues can acquire powerful motivational control over the behavior of
addicts, and can contribute to relapse via multiple, dissociable mechanisms. Most preclinical …

Cocaine-induced reinstatement in rats: evidence for a critical role of cocaine stimulus properties

R Keiflin, E Isingrini, M Cador - Psychopharmacology, 2008 - Springer
Rationale The exact behavioral nature of drug-induced reinstatement of drug seeking is still
debated. As an incentive, the drug can have general facilitatory influences on appetitive …

Reinstatement in a cocaine versus food choice situation: reversal of preference between drug and non‐drug rewards

BJ Tunstall, DN Kearns - Addiction biology, 2014 - Wiley Online Library
Recent studies show that when given a mutually exclusive choice between cocaine and
food, rats almost exclusively choose food. The present experiment investigated potential …

Pavlovian-to-instrumental transfer in cocaine seeking rats.

KH LeBlanc, SB Ostlund, NT Maidment - Behavioral neuroscience, 2012 - psycnet.apa.org
Drug-associated cues are believed to be important mediators of addiction and drug relapse.
Although such cues may influence drug-seeking behavior through multiple routes, it is their …

Extended cocaine-seeking produces a shift from goal-directed to habitual responding in rats

KC Leong, CR Berini, SM Ghee, CM Reichel - Physiology & behavior, 2016 - Elsevier
Cocaine addiction is often characterized by a rigid pattern of behavior in which cocaine
users continue seeking and taking drug despite negative consequences associated with its …