Lysophosphatidic acid (LPA) is a bioactive lipid enriched in the tumor microenvironment of
immunosuppressive malignancies such as ovarian cancer. Although LPA enhances the …

The tumor microenvironment (TME) may be best conceptualized as an ecosystem
comprised of cancer cells interacting with a multitude of stromal components such as the …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

Ovarian carcinoma is the deadliest type of gynecological cancer. The unique tumor
microenvironment enables specific and efficient metastasis, weakens immunological …

CD8 T lymphocytes are able to eliminate nascent tumor cells through a process referred to
as immunosurveillance. However, multiple inhibitory mechanisms within the tumor …

The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and
metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator …

Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main
membrane‐derived lipid signaling molecules. LPA acts as an autocrine/paracrine …

Bioactive lysophospholipid, lysophosphatidic acid (LPA), is consistently raised in the ascites
of patients with ovarian cancer. Interleukin-6 (IL-6) is a pleiotropic cytokine, which is …

Lysophosphatidic acid (LPA), a bioactive phospholipid, stimulates survival, proliferation,
adhesion, migration and invasion of ovarian cancer cells through the activation of G-protein …

As one of the important cancer hallmarks, metabolism reprogramming, including lipid
metabolism alterations, occurs in tumor cells and the tumor microenvironment (TME). It plays …