Abstract ABD-Derived Affinity Proteins (ADAPTs) is a novel class of engineered scaffold
proteins derived from an albumin-binding domain of protein G. The use of ADAPT6 …

Objectifs Les intégrines sont des récepteurs cellulaires capables de se lier au cytosquelette
d'actine et permettant à la cellule d'interagir avec son environnement. En oncologie, elles …

Visualizing and manipulating the behavior of proteins is crucial to understanding the
physiology of the cell. Methods of biorthogonal protein labeling are important tools to attain …

While copper is an essential micronutrient in all living organisms, copper misregulation in
humans is associated with neurodegenerative disorders such as Menkes and Wilson's …

We have developed a novel radiogallium (Ga)–DOTA-based bivalent peptidic ligand
targeting a chemokine receptor, CXCR4, for tumor imaging. A CXCR4 imaging probe with …

[en] The high specificity and strong affinity (Kd= 10-15 M) of avidin for biotin plays a
significant role in the two-step pre targeting protocol based on administration of the avidin …

Abstract Purpose Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant
tumour progression. For the imaging of HIF-1-active tumours, we previously developed a …

INTRODUCTION: Affibody molecules, small scaffold proteins, have demonstrated an
appreciable potential as imaging probes. Affibody molecules are composed of three alpha …

Introduction Radiolabeled antibodies are promising tools for cancer diagnosis using nuclear
medicine. A DOTA-chelating system is useful for preparing immuno-positron emission …

241436 Introduction: Radioimmunotherapy (RIT) is an important treatment modality for
difficult-to-treat metastatic cancers, yet conventional one-step RIT with monoclonal antibody …