Aging is a major risk factor for individuals' health problems. Moreover, environmental signals
have a widespread influence on the aging process. Epigenetic modification, eg DNA …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …

DNA methylation involves the covalent transfer of a methyl group to the C-5 position of the
cytosine ring on a DNA strand. DNA methylation is both heritable and modifiable and can …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

The biochemistry of aging is complex, with biologically significant changes occurring in
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …

Human longevity is influenced by both inherited and environmental factors. Alterations in
gene function that are related to inherited genetic mutations and polymorphisms can explain …

Aging is a multi-factorial process of the progressive gradual decline of cellular functions with
the passage of time. It is clear that aging affects the mammalian epigenome, including …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Ageing is characterised by a physical decline in biological functioning which results in a
progressive risk of mortality with time. As a biological phenomenon, it is underpinned by the …

DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the
genome. Age is one of these factors. Age causes characteristic DNAm changes that are …