The Pharmacology of Intravenous Opioids

S Whitener, MD McEvoy, SL Shafer, P Flood - Geriatric Anesthesiology, 2018 - Springer
This chapter reviews the pharmacology of the intravenously administered opioids in the
practice of geriatric anesthesiology. These drugs include morphine, meperidine …

The pharmacology of opioids

SL Shafer, P Flood - Geriatric anesthesiology, 2008 - Springer
There are a lot of old people. In the 1990 census, patients over the age of 65 comprised 12%
of the United States population, or 30,000,000 people. That grew modestly, to 12.5%, by …

The pharmacology of anesthetic drugs in elderly patients

SL Shafer - Anesthesiology clinics of North america, 2000 - Elsevier
Elderly patients need smaller doses of anesthetic drugs than younger patients. This is
clinically obvious. Based on both teaching and experience, anesthesiologists have learned …

Use of opioids in the elderly--pharmacokinetic and pharmacodynamic considerations

E Freye, JV Levy - Anasthesiologie, Intensivmedizin, Notfallmedizin …, 2004 - europepmc.org
Perioperative management of geriatric patients is becoming an important component in
anaesthetic practice in the 21st century. This phenomenon is due to the fact that people …

Opioid analgesic drugs in the elderly.

WB Forman - Clinics in geriatric medicine, 1996 - europepmc.org
Much is known about opioid metabolism, which is critical in administering these agents to
the elderly. Fear of addiction and tolerance are the major barriers to their use among …

Geriatric pharmacology

S Akhtar, R Ramani - Anesthesiology Clinics, 2015 - anesthesiology.theclinics.com
The aging process is characterized by a significant level of complexity, which makes the
perioperative care of the elderly patients extremely challenging. Typically, elderly patients …

Rational opioid dosing in the elderly: dose and dosing interval when initiating opioid therapy

DK Gupta, MJ Avram - Clinical Pharmacology & Therapeutics, 2012 - Wiley Online Library
Opioids are the mainstay of treatment for moderate to severe pain. 1 However, opioid
therapy in the elderly is often associated with significant morbidity because of excessive …

Opioid use in the elderly

OHG Wilder-Smith - European Journal of Pain, 2005 - Elsevier
Pain treatment in the elderly is an important challenge to Western societies due to
increasing numbers of old persons, their higher incidence of pain, and their greater …

The role of newer opioids in geriatric anesthesia.

SL Shafer - Acta Anaesthesiologica Belgica, 1998 - europepmc.org
The unique features of remifentanil are its rapid clearance and rapid ke0, resulting in a rapid
onset and offset of drug effect. It is tempting to speculate that these characteristics will make …

Pharmacokinetic and Pharmacodynamic Changes in the Elderly: Impact on Anesthetics

E Coetzee, AR Absalom - Anesthesiology clinics, 2023 - anesthesiology.theclinics.com
Anesthesiologists are increasingly being involved in the care of elderly and frail patients
because of considerable changes in population demographics, coupled with significant …