[HTML][HTML] Effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on angiotensin-converting enzyme 2 levels: a comprehensive analysis …

G Kriszta, Z Kriszta, S Vancsa, PJ Hegyi… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the pathogen of
coronavirus disease 2019 (COVID‐19), caused the outbreak escalated to pandemic …

[HTML][HTML] Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 …

P Reus, AK Schneider, T Ulshöfer, M Henke, D Bojkova… - Life, 2021 - mdpi.com
Blood-pressure-lowering drugs are proposed to foster SARS-CoV-2 infection by
pharmacological upregulation of angiotensin-converting enzyme 2 (ACE2), the binding …

Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019

MY Liu, B Zheng, Y Zhang, JP Li - Chronic Diseases and …, 2020 - mednexus.org
Coronavirus disease 2019 is a major threat to public health globally. Though its
pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has …

Renin-angiotensin system at the interface of COVID-19 infection

R Gul, UH Kim, AA Alfadda - European Journal of Pharmacology, 2021 - Elsevier
Abstract Angiotensin-converting enzyme 2 (ACE2) has been recognized as a potential entry
receptor for SARS-CoV-2 infection. Binding of SARS-CoV-2 to ACE2 allows engagement …

Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?

F Simko, T Baka - Clinical Science, 2021 - portlandpress.com
Abstract Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective
renin–angiotensin system (RAS) pathway but also the entry receptor for severe acute …

[HTML][HTML] Angiotensin II promotes SARS-CoV-2 Infection via upregulation of ACE2 in human bronchial cells

I Caputo, B Caroccia, I Frasson, E Poggio… - International Journal of …, 2022 - mdpi.com
Blockers of the renin-angiotensin system (RAS) have been reported to increase the
angiotensin converting enzyme (ACE) 2, the cellular receptor of SARS-CoV-2, and thus the …

The Controversy of Renin–Angiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection

AS Manolis, TA Manolis, AA Manolis… - Journal of …, 2020 - journals.lww.com
The ongoing COVID-19 pandemic has produced serious turmoil world-wide. Lung injury
causing acute respiratory distress syndrome seems to be a most dreaded complication …

Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19

H Cheng, Y Wang, GQ Wang - Journal of medical virology, 2020 - Wiley Online Library
This article reviews the correlation between angiotensin‐converting enzyme 2 (ACE2) and
severe risk factors for coronavirus disease 2019 (COVID‐19) and the possible mechanisms …

[HTML][HTML] Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19

H Kai, M Kai - Hypertension Research, 2020 - nature.com
The rapid spread of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has led to an ongoing pandemic of coronavirus disease 2019 (COVID-19) …

Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19

MA Pedrosa, R Valenzuela, P Garrido-Gil… - Clinical …, 2021 - portlandpress.com
The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-
converting enzyme 2), which acts as a double-edged sword, because ACE2 increases the …