Drug resistance is the main responsible for chemotherapy failure in ovarian cancer
treatment. In this study, we looked at increasing the anticancer effect of paclitaxel (PTX) …

We have designed and developed an effective drug delivery system using biocompatible
polymer of poly (ethylene glycol)-polyaspartic acid (mPEG-PAsp) for co-loading the …

Adenocarcinoma is the most lethal gynecologic tumor and treatment usually consists in
surgery followed by chemotherapy. However, the chemotherapy benefits are eventually …

Paclitaxel is one of the anticancer agents most often used in clinical oncology practice for
the treatment of ovarian, breast and non-small cell lung cancers. Nanoengineered polymeric …

The combination of chemotherapy drugs and multidrug-resistant reversing agents for
treating multidrug resistance in tumors has attracted increasing attention. However, the poor …

Paclitaxel-loaded hyaluronan solid nanoemulsions (PTX-HSNs) were successfully
fabricated for the delivery of PTX to improve ovarian cancer treatment via active tumor …

Paclitaxel (PTX) is one of the most effective chemotherapeutic drugs for the treatment of a
variety of cancers. However, it is associated with serious side effects caused by PTX itself …

Ovarian carcinoma (OC) is one of the leading causes of death among gynecologic
malignancies all over the world. It is characterized by high mortality rate because of the lack …

Objective: Most primary human ovarian tumors and peritoneal implants, as well as tumor
vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural …

Purpose The aim of this study was to test the ability of paclitaxel-loaded poly
(butylcyanoacrylate)(PBCA) nanoparticles to overcome multidrug resistance (MDR) in …