Rewiring the functional complexity between Crc, Hfq and sRNAs to regulate carbon catabolite repression in Pseudomonas

K Bharwad, S Rajkumar - World Journal of Microbiology and …, 2019 - Springer
Pseudomonas species are the most versatile of all known bacteria for metabolic flexibility
and the extent of host range from plants to humans that remains unmatched. The evolution …

Carbon catabolite repression in Pseudomonas: optimizing metabolic versatility and interactions with the environment

F Rojo - FEMS microbiology reviews, 2010 - academic.oup.com
Metabolically versatile free-living bacteria have global regulation systems that allow cells to
selectively assimilate a preferred compound among a mixture of several potential carbon …

In vivo genetic analysis of Pseudomonas aeruginosa carbon catabolic repression through the study of CrcZ pseudo-revertants shows that Crc-mediated metabolic …

T Gil-Gil, JR Valverde, JL Martínez… - Microbiology …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic bacterial pathogen able to colonize a variety
of habitats. Its success in colonizing these habitats relies on its metabolic robustness and its …

[HTML][HTML] Crossing bacterial boundaries: the carbon catabolite repression system Crc-Hfq of Pseudomonas putida KT2440 as a tool to control translation in E. Coli

C Lu, TP Ramalho, MMM Bisschops, RH Wijffels… - New …, 2023 - Elsevier
As a global regulatory mechanism, carbon catabolite repression allows bacteria and
eukaryal microbes to preferentially utilize certain substrates from a mixture of carbon …

Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression

E Sonnleitner, U Bläsi - PLoS Genetics, 2014 - journals.plos.org
Carbon Catabolite repression (CCR) allows a fast adaptation of Bacteria to changing
nutrient supplies. The Pseudomonas aeruginosa (PAO1) catabolite repression control …

Novel Targets of the CbrAB/Crc Carbon Catabolite Control System Revealed by Transcript Abundance in Pseudomonas aeruginosa

E Sonnleitner, M Valentini, N Wenner, FZ Haichar… - PloS one, 2012 - journals.plos.org
The opportunistic human pathogen Pseudomonas aeruginosa is able to utilize a wide range
of carbon and nitrogen compounds, allowing it to grow in vastly different environments. The …

Two small RNAs, CrcY and CrcZ, act in concert to sequester the Crc global regulator in Pseudomonas putida, modulating catabolite repression

R Moreno, P Fonseca, F Rojo - Molecular microbiology, 2012 - Wiley Online Library
The Crc protein is a translational repressor that recognizes a specific target at some mRNAs,
controlling catabolite repression and co‐ordinating carbon metabolism in pseudomonads. In …

The Crc/CrcZ‐CrcY global regulatory system helps the integration of gluconeogenic and glycolytic metabolism in Pseudomonas putida

R La Rosa, J Nogales, F Rojo - Environmental microbiology, 2015 - Wiley Online Library
In metabolically versatile bacteria, carbon catabolite repression (CCR) facilitates the
preferential assimilation of the most efficient carbon sources, improving growth rates and …

Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control

E Sonnleitner, F Bassani, A Cianciulli Sesso… - Frontiers in …, 2023 - frontiersin.org
In the opportunistic human pathogen Pseudomonas aeruginosa (Pae), c arbon c atabolite r
epression (CCR) orchestrates the hierarchical utilization of N and C sources, and impacts …

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria

P Browne, M Barret, F O'Gara, JP Morrissey - BMC microbiology, 2010 - Springer
Background Catabolite repression control (CRC) is an important global control system in
Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a …