Docetaxel (DTX) proved one of the most effective active pharmaceutical ingredients (APIs)
for the treatment of cancers. However, in respect of its low solubility and high lipophilic …

Lung cancer remains the leading cause of cancer associated deaths worldwide. Recent
efforts have been focused on combinational and nanoparticulate therapies that can …

Pulmonary delivery offers an attractive route of administration for chemotherapeutic agents,
with the advantages of high drug concentrations locally and low side effects systemically …

Background: Pulmonary drug delivery is attractive for both local and systemic drug delivery
as a non-invasive route that provides a large surface area, thin epithelial barrier, high blood …

A rapid, simple and sensitive ultra fast liquid chromatography–tandem mass spectrometry
(UFLC–MS/MS) method coupled with one-step protein precipitation procedure has been …

Aim: The use of inhalable nanomedicines can overcome the Enhanced permeation and
retention effect (EPR)-associated drawbacks in lung cancer therapy via systemic …

CXCR4 is a chemokine receptor which is over expressed in multiple cancers including lung
cancers. LFC131 peptide (d-Tyr-Arg-Arg-2-Nal-Gly), an inhibitor of CXCR4-ligand binding, is …

Background: Solid lipid nanoparticles (SLNs) is the drug delivery system that has the
capability to improve drug release at the desired tumor site. The aim of the present study is …

Abstract Treatment complexities and the cytotoxicity of anticancer drugs to normal cells often
results in therapeutic failure. Biodegradable nanoparticles have gained attention as drug …

Nanocarriers decorated with different ligands were used to achieve lung cancer treatment.
Surface decoration of nanoparticulate system will assist in targeting the drug to specific …