Endosomal escape and delivery of CRISPR/Cas9 genome editing machinery enabled by nanoscale zeolitic imidazolate framework
CRISPR/Cas9 is a combined protein (Cas9) and an engineered single guide RNA (sgRNA)
genome editing platform that offers revolutionary solutions to genetic diseases. It has …
genome editing platform that offers revolutionary solutions to genetic diseases. It has …
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …
palindromic repeats) gene editing system often require viral vectors, which pose safety …
CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation
CRISPR-Cas12a represents an efficient tool for genome editing in addition to the
extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery …
extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery …
Tissue-specific delivery of CRISPR therapeutics: Strategies and mechanisms of non-viral vectors
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing
system has been the focus of intense research in the last decade due to its superior ability to …
system has been the focus of intense research in the last decade due to its superior ability to …
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications
The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …
Reversible RNA acylation for control of CRISPR–Cas9 gene editing
M Habibian, C McKinlay, TR Blake, AM Kietrys… - Chemical …, 2020 - pubs.rsc.org
We report the development of post-transcriptional chemical methods that enable control over
CRISPR–Cas9 gene editing activity both in in vitro assays and in living cells. We show that …
CRISPR–Cas9 gene editing activity both in in vitro assays and in living cells. We show that …
Nanoparticle delivery of CRISPR/Cas9 for genome editing
L Duan, K Ouyang, X Xu, L Xu, C Wen, X Zhou… - Frontiers in …, 2021 - frontiersin.org
The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-
associated system (Cas) gene-editing system represents a promising tool for genome …
associated system (Cas) gene-editing system represents a promising tool for genome …
Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing
RISPR-Cas9 has exhibited enormous potential in gene therapy. It can perform genome
editing with single-nucleotide precision in various types of cell and tissue, providing a …
editing with single-nucleotide precision in various types of cell and tissue, providing a …
CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery
Genome editing offers promising solutions to genetic disorders by editing DNA sequences
or modulating gene expression. The clustered regularly interspaced short palindromic …
or modulating gene expression. The clustered regularly interspaced short palindromic …
Direct cytosolic delivery of CRISPR/Cas9-ribonucleoprotein for efficient gene editing
Genome editing through the delivery of CRISPR/Cas9-ribonucleoprotein (Cas9-RNP)
reduces unwanted gene targeting and avoids integrational mutagenesis that can occur …
reduces unwanted gene targeting and avoids integrational mutagenesis that can occur …