The most widely studied polymorphisms of the ABCB1 gene are rs1128503 (c. 1236C> T),
rs2032582 (c. 2677G> T/A), and rs1045642 (c. 3435C> T). Although variation in ABCB1 …

Purpose: To determine the frequencies of important allelic variants and their haplotype
frequencies of the gene among Jordanian population and to compare findings with those …

Introduction: The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes
for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer …

Introduction: Interethnic admixture is a source of cryptic population structure that may lead to
spurious genotype–phenotype associations in pharmacogenomic studies. We studied the …

Abstract The ABCB1/MDR-1 gene, which encodes P-glycoprotein, is highly polymorphic. We
analyzed 278 healthy Brazilian individuals through PCR–RFLP to identify ABCB1 variants …

As functional ABCB1 haplotypes were recently reported in the promoter region of the gene,
we resequenced the ABCB1 distal promoter region, along with other regions (the enhancer …

Objective Promoter single-nucleotide polymorphisms (SNPs) of the ABCB1 gene, encoding
the placental efflux transporter P-glycoprotein, can affect its expression and alter xenobiotic …

The ATP‐binding cassette (ABC) transporter ABCB1, or P‐glycoprotein, is a transmembrane
efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 …

Background As a major mediator in the complex interplay between humans and the
xenobiotic environment, the ABCBI transporter gene is an obvious candidate for …

The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux
pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of …