Monitoring of hepatic function during amiodarone therapy

PT Pollak, YD You - American Journal of Cardiology, 2003 - ajconline.org
After many years of benign use in Europe, amiodarone developed a reputation for frequent
adverse effects after its introduction to North America at higher doses. 1, 2 Two decades …

[HTML][HTML] The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice

HL Kim, JB Seo, WY Chung, SH Kim… - The Korean Journal of …, 2014 - ncbi.nlm.nih.gov
Methods Between January 1, 2000 and March 10, 2012, a total of 930 consecutive patients
who had been treated with amiodarone for arrhythmia were reviewed retrospectively. An …

[HTML][HTML] N-acetylcysteine treats intravenous amiodarone induced liver injury

ML Mudalel, KP Dave, JP Hummel… - World Journal of …, 2015 - ncbi.nlm.nih.gov
We report a case of intravenous (IV) amiodarone drug induced liver injury (DILI). The patient
received IV N-acetylcysteine (NAC) which resulted in a rapid improvement in liver enzymes …

How toxic is amiodarone to the liver?

PT Pollak - Journal of Gastrointestinal & Liver Diseases, 2010 - search.ebscohost.com
The article discusses the effects of myocardial depressant amiodarone to the liver.
According to some studies, the cardiovascular agents can be shown to have a concentration …

Acute liver and renal failure: a rare adverse effect exclusive to intravenous form of amiodarone

R Paudel, P Dogra, S Suman… - Case Reports in …, 2016 - Wiley Online Library
Amiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of
ventricular tachyarrhythmias making it irreplaceable in certain group of patients. We report …

[HTML][HTML] Amiodarone-induced hepatotoxicity—quantitative measurement of iodine density in the liver using dual-energy computed tomography: Three case reports

HJ Lv, HW Zhao - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
BACKGROUND Amiodarone is the drug most commonly used to manage arrhythmias. Long-
term amiodarone administration causes hepatotoxicity due to iodine accumulation in the …

A comparison of three different sources of data in assessing the frequencies of adverse reactions to amiodarone

YK Loke, S Derry, JK Aronson - British journal of clinical …, 2004 - Wiley Online Library
Aims To compare the frequencies of adverse drug reactions (ADRs) to amiodarone from
three separate datasets:(i) a meta‐analysis of clinical trials,(ii) spontaneous reports …

Pleiotropic actions of amiodarone: still puzzling after half a century

J Heijman, D Dobrev - Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 - Springer
Amiodarone was developed in the early 1960s based on extracts from the Khella plant and
was initially used as a coronary dilator for the treatment of angina pectoris (Singh 2008). In …

Monitoring amiodarone's toxicities: recommendations, evidence, and clinical practice

HT Stelfox, SB Ahmed, J Fiskio… - Clinical Pharmacology & …, 2004 - Wiley Online Library
Objectives We sought to develop an explicit evidence‐based model of medication
monitoring and to evaluate monitoring practices and adverse drug events in patients taking …

Liver and thyroid monitoring in ambulatory patients prescribed amiodarone in 10 HMOs

MA Raebel, NM Carroll, SR Simon, SE Andrade… - Journal of Managed …, 2006 - jmcp.org
BACKGROUND: Amiodarone can cause liver and thyroid toxicity, but little is known about
compliance with laboratory tests to evaluate liver and thyroid function among ambulatory …