Introduction Cancer is a big challenge of the 21 century, whose defeat requires efficient
antitumor drugs. Objectives The paper aims to investigate the synergistic effect of two …

The paper aims to investigate the antitumor activity of a series of phenothiazine derivatives
in order to establish a structure–antitumor activity relationship. To this end, PEGylated and …

Research for discovering chemical entities with antiproliferative properties to combat
globally rising cancer cases has witnessed tremendous interest in recent years …

Phenothiazines (PTZs) are a group of compounds characterized by the presence of the 10H-
dibenzo-[b, e]-1, 4-thiazine system. PTZs used in clinics as antipsychotic drugs with other …

Phenothiazines are antipsychotic drugs used in the treatment of psychosis, including
schizophrenia. Until the discovery of the phenothiazine derivative chlorpromazine at the …

Background: Cancer incidence and mortality have been increasing and cancer is still the
leading cause of death all over the world. Despite the enormous progress in cancer …

The paper reports a series of three new PEGylated phenothiazine derivatives which keep
the potential of valuable building blocks for preparing eco-materials addressed to a large …

Cancer is a leading cause of death worldwide and there are still limited options for cure.
Chemotherapy is the most significant treatment for cancer which increased survival rates …

Cancer therapy is challenging for scientists because of low effectiveness of so far existing
therapies (especially in case of great invasiveness and advanced tumor stage). Such need …

Some (E)-3-(3-(4-(benzyloxy) phenyl)-1-phenyl-1 H-pyrazol-4-yl)-1-phenylprop-2-en-1-one
conjugates 5a–r were designed; synthesized; characterized by 1H, 13C NMR, and ESI-MS; …