Gene expression analysis of astrocyte and microglia endocannabinoid signaling during autoimmune demyelination

Á Moreno-García, A Bernal-Chico, T Colomer… - Biomolecules, 2020 - mdpi.com
The endocannabinoid system is associated with protective effects in multiple sclerosis (MS)
that involve attenuated innate immune cell responses. Astrocytes and microglia are …

The dynamic role of microglia and the endocannabinoid system in neuroinflammation

AP Young, EM Denovan-Wright - Frontiers in Pharmacology, 2022 - frontiersin.org
Microglia, the resident immune cells of the brain, can take on a range of pro-or anti-
inflammatory phenotypes to maintain homeostasis. However, the sustained activation of pro …

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

M Mecha, A Feliú, FJ Carrillo-Salinas… - Brain, behavior, and …, 2015 - Elsevier
The ability of microglia to acquire diverse states of activation, or phenotypes, reflects
different features that are determinant for their contribution to homeostasis in the adult CNS …

Cannabinoids and experimental models of multiple sclerosis

I Kubajewska, CS Constantinescu - Immunobiology, 2010 - Elsevier
The inflammatory response is a hallmark in the development of autoimmune-mediated
neurodegenerative diseases of the central nervous system (CNS). Research on these …

Endocannabinoid modulation of microglial phenotypes in neuropathology

M Tanaka, S Sackett, Y Zhang - Frontiers in Neurology, 2020 - frontiersin.org
Microglia, the resident immune cells of the central nervous system, mediate brain
homeostasis by controlling neuronal proliferation/differentiation and synaptic activity. In …

The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis

D Centonze, M Bari, S Rossi, C Prosperetti, R Furlan… - Brain, 2007 - academic.oup.com
The ability of cannabinoids to modulate both inflammatory and degenerative neuronal
damage prompted investigations on the potential benefits of such compounds in multiple …

Synthetic cannabinoids reduce the inflammatory activity of microglia and subsequently improve neuronal survival in vitro

AP Young, EM Denovan-Wright - Brain, Behavior, and Immunity, 2022 - Elsevier
Microglia are resident immune cells of the brain that survey the microenvironment, provide
trophic support to neurons, and clear debris to maintain homeostasis and healthy brain …

The microglial endocannabinoid system is similarly regulated by lipopolysaccharide and interferon gamma

AP Young, EM Denovan-Wright - Journal of Neuroimmunology, 2022 - Elsevier
Perturbation of the endocannabinoid system can have profound effects on immune function
and synaptic plasticity. Microglia are one of few cell types with a self-contained …

The cannabinoid system and microglia in health and disease

SS Duffy, JP Hayes, NT Fiore, G Moalem-Taylor - Neuropharmacology, 2021 - Elsevier
Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

[HTML][HTML] Extracellular vesicles released by microglia and macrophages carry endocannabinoids which foster oligodendrocyte differentiation

M Lombardi, F Scaroni, M Gabrielli, S Raffaele… - Frontiers in …, 2024 - frontiersin.org
Introduction Microglia and macrophages can influence the evolution of myelin lesions
through the production of extracellular vesicles (EVs). While microglial EVs promote in vitro …