Given its remarkable property to easily switch between different oxidative states, iron is
essential in countless cellular functions which involve redox reactions. At the same time …

Erythropoietic porphyrias are caused by enzymatic dysfunctions in the heme biosynthetic
pathway, resulting in porphyrins accumulation in red blood cells. The porphyrins deposition …

Heme is a prosthetic group comprising ferrous iron (Fe 2+) and protoporphyrin IX and is an
essential cofactor in various biological processes such as oxygen transport (hemoglobin) …

Heme, which is composed of iron and the small organic molecule protoporphyrin, is an
essential component of hemoglobin as well as a variety of physiologically important …

Heme serves as the prosthetic group of various hemoproteins that carry out many essential
functions for cells. For example, the transport of oxygen is carried out by hemoglobin and …

Heme (iron protoporphyrin IX) exists as prosthetic group in several hemoproteins, which
include respiration cytochromes, gas sensors, P450 enzymes (CYPs), catalases …

Heme, like chlorophyll, is a primordial molecule and is one of the fundamental pigments of
life. Disorders of normal heme synthesis may cause human diseases, including certain …

Iron is a trace element that is important for many vital processes, including oxygen transport,
oxidative metabolism, cellular proliferation, and catalytic reactions. Iron supports these …

The porphyrias and the sideroblastic anemias are metabolic disorders that both involve
defects in heme biosynthesis. Most forms of porphyria are inherited as Mendelian autosomal …

Heme is a porphyrin ring complexed with ferrous iron and protoporphyrin IX. Heme is an
essential prosthetic group in proteins that is necessary as a subcellular compartment to …