Colorectal cancer is a major worldwide health care problem that accounts for 1 million new
cases each year. The risk factors for this disease include hereditary factors, environmental …

Colorectal cancer is the third common cancer in this world, accounting for more than 1
million cases each year. However, detailed etiology and mechanism of colorectal cancer …

Abstract Cyclooxygenase-2 (COX-2) and its product prostaglandin E 2 (PGE 2) play a critical
role in development and progression of colorectal cancer. Yet the detailed mechanistic …

Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …

There is considerable interest in the involvement of cyclooxygenase-2 (COX-2) in colon
carcinogenesis and its progression, because nonsteroidal anti-inflammatory drugs (NSAIDs) …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Carcinoma of the colon and/or rectum represents the second most common gastrointestinal
malignancy worldwide. Despite this prevalence, current therapeutic regimens remain largely …

Background: Despite compelling evidence from the genetic background and clinical studies
indicating that cyclooxygenase-2 (COX2) up-regulation is a key step in carcinogenesis of …