Colorectal cancer (CRC) is an important cause of cancer-related deaths worldwide. Early
diagnosis and treatment of CRCs are of importance for improving the survival. In the present …

Cancer cells require nourishment for the growth of the primary tumor mass and spread of the
metastatic colony. These needs are fulfilled by tumor-associated neovasculature known as …

Recent studies have suggested the inhibition of cyclooxygenase-2 (COX-2) as strategy to
prevent colorectal cancer. In this study, the cytostatic and cytotoxic effects of different non …

Angiogenesis is a physiological process involving growth of new blood vessels from pre‐
existing ones; however, it also plays a critical role in tumor progression. It favors the …

Abstract Cyclooxygenase‐2 (COX‐2) inhibitors are effective chemopreventive agents
against colorectal cancers. For treatment of advanced cancers, combination of COX‐2 …

Initiation of malignancy is dependent upon the basic ratio of cell proliferation and apoptosis.
Many molecular proteins and pathways are responsible for the imbalance of proliferation …

Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive
agents against a variety of cancers owing to their capability in blocking the tumor …

BACKGROUND Standard non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of
colorectal cancer by 40–60% but the mechanism by which this occurs is uncertain. Selective …

Initiation of various cancers has been observed to be regulated via a prolonged
inflammatory state in the tissues. However, molecular role of such a localized inflammation …

ABSTRACT Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers, including colon cancer, and therefore the …