If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it
appeared useful to work out a theory explaining the complexity of this disease. More than …

There is a growing body of evidence supporting the etiologic implication of gap junctional
intercellular communication disorders in carcinogenesis. Substantial progress has recently …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …

In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

To develop a strategy for efficacious intervention in order to prevent or treat various cancers,
one must understand the basic mechanism (s) by which various anticancer dietary factors …

The development of many forms of intercellular communication was essential for the
evolution of multicellular organisms. The organization of cells into tissues and organs and …

This article is a report of the “International Colloquium on Gap junctions: 50 Years of Impact
on Cancer” that was held 8–9 September 2016, at the Amphitheater “Pôle Biologie Santé” of …

Publisher Summary This chapter focuses on the role of gap junctional intercellular
communication (GJIC) in cellular growth control and neoplasia and considers the large body …

The establishment of gap junctional intercellular communication is a prerequisite for
appropriate control of tissue homeostasis. Gap junctions consist of connexin proteins …