Intercellular communications are indispensable for the maintenance of homeostasis in the
multicellular organisms. Gap-type junctions are one of the most common and perhaps most …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Gap junction proteins are expressed in cancer stem cells and non-stem cancer cells of many
tumors. As the morphology and assembly of gap junction channels are crucial for their …

Early observations showed a lack of growth control and terminal differentiation with a lack of
gap junctional intercellular communication (GJIC). Subsequent observations showed that …

Direct communication between cells, mediated by gap junctions, is nowadays considered as
an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap …

Metastasis is a common phenomenon in the progression and dissemination of cancer. It is
estimated that metastasis accounts for 90% cancer-related mortality. Although the formation …

Understanding the process of carcinogenesis will involve both the accumulation of many
scientific facts derived from molecular, biochemical, cellular, physiological, whole animal …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

Gap junctions (GJs), essential structures for cell-cell communication, are made of two
hemichannels (commonly called connexons), one on each adjacent cell. Found in almost all …