Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …

Cell proliferation is an important process for reproduction, growth and renewal of living cells
and occurs in several situations during life. Cell proliferation is present in all the steps of …

Introduction 3. Evolution and cancer 4. Theories of carcinogenesis: Overview 5. Stem cell
versus the de-differentiation theories 6. Initiation/promotion/progression theory of …

Gap junctional intercellular communication (GJIC) is considered to play a key role in the
maintenance of tissue independence and homeostasis in multicellular organisms by …

Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-
formed plasma membrane channels that allow for the passage of small molecules between …

Formation of metastases negatively impacts the survival prognosis of cancer patients.
Globally, if the various steps involved in their formation are relatively well identified, the …

Tumour development is a process resulting from the disturbance of various cellular functions
including cell proliferation, adhesion and motility. While the role of these cell parameters in …

Animal tumor models have demonstrated a close correlation between gap junctional,
intercellular communication (GJIC) and tumor metastasis. To examine GJIC levels in human …

Connexin-and pannexin (Panx)-formed hemichannels (HCs) and gap junctions (GJs)
operate an interaction with the extracellular matrix and GJ intercellular communication …

Gap junctions, intercellular channels structured by the connexin protein family, have been
implicated in the control of cell homeostasis, proliferation, differentiation and death. A loss of …