Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Since carcinogenesis is a multi-stage, multi-mechanism process, involving mutagenic, cell
death and epigenetic mechanisms, during the “initiation/promotion/and progression” …

Gap junctions are comprised of proteinaceous, plasma membrane channels that link the
interiors of adjacent cells and permit cells to directly exchange small (< 1,000 Daltons) …

Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

Tissue homeostasis is the result of a complex intercellular network controlling the behavior
of every cell for the survival of the whole organism. In mammalian tissues, cells do …

The normal development and health of all multicellular organisms, including the human
being, depend on the adaptive maintenance of the integrity of the genetic information (eg …

Gap junctional intercellular communication (GJIC) is a form of cell–cell communication
mediating the exchange of small molecules between neighboring cells. Gap junctions (GJs) …

Gap‐junctional intercellular communication (GJIC) is involved in cellular growth control and
is often reduced in neoplastic cells. In this study, four GJIC‐deficient rat liver epithelial cell …

Gap junctional communication (GJC) is mediated by channels consisting of connexins and
can be differentially regulated by ions, second messengers, kinases, phosphatases, and cell …