α‐Linolenic acid metabolism in adult humans: the effects of gender and age on conversion to longer‐chain polyunsaturated fatty acids

GC Burdge, PC Calder - European Journal of Lipid Science …, 2005 - Wiley Online Library
This review summarises and evaluates current knowledge of α‐linolenic acid (αLNA)
metabolism in adult humans. The principal biological role of αLNA appears to be as a …

Conversion of -linolenic acid to longer-chain polyunsaturated fatty acids in human adults

GC Burdge, PC Calder - Reproduction Nutrition Development, 2005 - rnd.edpsciences.org
The principal biological role of $\alpha $-linolenic acid ($\alpha $ LNA; 18: 3n-3) appears to
be as a precursor for the synthesis of longer chain n-3 polyunsaturated fatty acids (PUFA) …

α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans

JT Brenna, N Salem Jr, AJ Sinclair… - … leukotrienes and essential …, 2009 - Elsevier
Blood levels of polyunsaturated fatty acids (PUFA) are considered biomarkers of status.
Alpha-linolenic acid, ALA, the plant omega-3, is the dietary precursor for the long-chain …

α‐linolenic acid interconversion is sufficient as a source of longer chain ω‐3 polyunsaturated fatty acids in humans: An opinion

GC Burdge - Lipids, 2022 - Wiley Online Library
Abstract α‐linolenic acid (αLNA) conversion into the functionally important ω‐3
polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), and docosahexaenoic …

Dietary α-linolenic acid and health-related outcomes: a metabolic perspective

GC Burdge, PC Calder - Nutrition research reviews, 2006 - cambridge.org
α-Linolenic acid (αLNA; 18: 3n-3) is essential in the human diet, probably because it is the
substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids, principally EPA …

Effects of age and dietary n‐3 fatty acids on the metabolism of [13C]‐α‐linolenic acid

SHF Vermunt, RP Mensink, AMG Simonis, G Hornstra - Lipids, 1999 - Wiley Online Library
Conclusion We conclude that13C α‐linolenic acid is converted into its LCP. The conversion
of α‐linolenic acid into its LCP appears to be inhibited on diets rich in EPA/DHA, while it …

α-Linolenic acid metabolism in men and women: nutritional and biological implications

G Burdge - Current Opinion in Clinical Nutrition & Metabolic Care, 2004 - journals.lww.com
Overall, α-linolenic acid appears to be a limited source of longer-chain n-3 fatty acids in man
and so adequate intakes of preformed n-3 polyunsaturated fatty acids, in particular …

Metabolism of α-linolenic acid in humans

GC Burdge - Prostaglandins, leukotrienes and essential fatty acids, 2006 - Elsevier
α-Linolenic acid (18: 3n-3) is essential in the human diet, probably because it is the
substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids …

Gender differences in the n-3 fatty acid content of tissues

CE Childs, M Romeu-Nadal, GC Burdge… - Proceedings of the …, 2008 - cambridge.org
Dietary n-3 PUFA have many beneficial effects on cell and tissue function and on human
health. In mammals the n-3 essential fatty acid α-linolenic acid (ALNA) can be converted into …

Conversion of linoleic acid and alpha‐linolenic acid to long‐chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of …

RA Gibson, B Muhlhausler… - Maternal & child …, 2011 - Wiley Online Library
Over the past two decades, there has been a marked shift in the fatty acid composition of the
diets of industrialized nations towards increased intake of the n‐6 fatty acid linoleic acid (LA …