Optical spectroscopy has been intensively studied for cancer management in the past two
decades. This review paper first introduces the background of optical spectroscopy for …

The shifting metabolic landscape of aggressive tumors, with fluctuating oxygenation
conditions and temporal changes in glycolysis and mitochondrial metabolism, is a critical …

The feasibility of using quantitative diffuse reflectance spectroscopy to longitudinally monitor
physiological response to cancer therapy was evaluated in a preclinical model. This study …

Background Among modern methods of tumor diagnosis, fluorescent methods are
considered one of the most prospective. Diagnostic agents (DAs) spread throughout the …

The spectral changes of native fluorophores among normal fibroblasts and cancer cell lines
of different metastatic ability are investigated by fluorescence spectroscopy. The normal …

Much effort is currently being placed into developing new blood tests for cancer diagnosis in
the hope of moving cancer diagnosis earlier and by less invasive means than current …

We are interested in investigating whether cancer therapy may alter the mitochondrial redox
state in cancer cells to inhibit their growth and survival. The redox state can be imaged by …

Label-free methods neither cause cell damage nor contribute to any change in cell
composition and intrinsic characteristics. Indeed, there is much interest in the scientific …

The goal of this study is to validate fluorescence intensity and lifetime imaging of metabolic
co‐enzymes NAD (P) H and FAD (optical metabolic imaging, or OMI) as a method to quantify …

The accurate identification of the human brain tumor boundary and the complete resection of
the tumor are two essential factors for the removal of the glioma tumor in brain surgery. We …