Myocardial infarction (MI) is the leading cause of mortality worldwide. Interleukin (IL)-33 (IL-
33) is a cytokine present in most cardiac cells and is secreted on necrosis where it acts as a …

Background—ST2 is an interleukin (IL)-1 receptor family member with membrane-bound
(ST2L) and soluble (sST2) isoforms, and sST2 is a biomarker for poor outcome in patients …

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family and is believed to play
important roles in different diseases by binding to its specific receptor suppression of …

Interleukin-33 (IL-33) is a recently described member of the IL-1 family of cytokines, which
was identified as a ligand for the ST2 receptor. Components of the IL-33/ST2 system were …

Background—IL-33 through its receptor ST2 protects the heart from myocardial infarct and
hypertrophy in animal models but, paradoxically, increases autoimmune disease. In this …

The inflammatory response has adverse effects on left ventricular (LV) function and
remodeling post-myocardial infarction (MI). Interleukin (IL)-33 is considered to have anti …

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …

ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2)
isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels …

Several studies have identified the importance of pro-inflammatory mediators in the
development and progression of cardiac disease such as heart failure (HF). Recently, a …

Interleukin-33 (IL-33) is a recently described member of the interleukin-1 (IL-1) family. It is
produced by diverse cell types in response to a variety of stresses including hemorrhage …