Despite advances in promoting axonal regeneration after acute spinal cord injury (SCI),
elicitation of bridging axon regeneration after chronic SCI remains a formidable challenge …

Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …

Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

During the past decades, new insights into mechanisms that limit plasticity and functional
recovery after spinal cord injury have spurred the development of novel approaches to …

Detailed pathophysiological findings of secondary damage phenomena after spinal cord
injury (SCI) as well as the identification of inhibitory and neurotrophic proteins have yielded …

Spinal cord injury results in acute as well as progressive secondary destruction of local and
distant nervous tissue through a number of degenerative mechanisms. Spinal cord injury …

Spinal cord injury (SCI) often induces loss of motor and/or sensory function below the level
of injury. While deficits persist in complete lesions, partial lesions of the spinal cord can be …

Traumatic injury to the peripheral and central nervous systems very often causes axotomy,
where an axon loses connections with its target resulting in loss of function. The axon …

Highlights•Grafted neural stem cells extend high numbers of axons over long distances after
spinal cord injury.•Graft derived axons make synaptic connections with host neurons.•Host …

Eight weeks post contusive spinal cord injury, we built a peripheral nerve graft bridge (PNG)
through the cystic cavity and treated the graft/host interface with acidic fibroblast growth …