Several studies suggest that impaired cholinergic function plays an important role in the
memory and cognitive deficits of normal aging. Numerous neurochemical studies performed …

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …

The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …

Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

A review of studies on nicotinic cholinergic receptors in human brain is presented. The
paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies …

The main objective of the present study was to determine whether cholinergic markers
(choline acetyl‐transferase activity and nicotinic and muscarinic receptors) are altered in …

Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding
sites in Alzheimer's disease. Using monoclonal antibodies we studied …

The status of various cholinergic markers was compared in Alzheimer's and Parkinson's
diseases. Rather unexpectedly, similar decrements were observed in choline …

Research into the pathogenesis of Alzheimer's Disease (AD) has increased steadily over
recent years, with efforts focused on the differences between alterations of neural activity in …