In the period immediately prior to publication of the first reports of cholinergic markers in the
brains of patients with Alzheimer's disease, there was very little hard science going on in this …

The cholinergic deficit in Alzheimer's disease (AD) brain has given rise to numerous
pharmacological strategies designed to enhance cholinergic metabolism and efficacy and …

A general review of cholinergic receptors in human brain is presented. The paper focuses
upon changes in normal aging brain and in Alzheimer disease. Studies from five different …

Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities have been
examined postmortem in a series of 66 individuals with no evidence of CNS disease …

Alzheimer's disease (AD), has been linked to abnormalities in several neurotransmitter and
neuropeptide systems. Central noradrenergic, serotonergic, somatostatinergic and CRF …

We have recently reported on the differential alterations of various cholinergic markers in
cortical and subcortical regions in Alzheimer's disease (AD). The main purpose of the …

The cholinergic hypothesis of Alzheimer's disease (AD) states 1. that cholinergic neurons in
the basal forebrain are severely affected in the course of disease, detectable both …

Impairment of cholinergic neurotransmission is a well-established fact in Alzheimer's
disease (AD) but there is controversy about its relevance at the early stages of the disease …

Great emphasis is being placed on identification of neurotransmitter systems involved in the
symptomatic manifestations of neurological and psychiatric disorders. In the case of …

Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr
of death and examined for indices of presynaptic cholinergic function. Consistent with loss of …