Autopsy studies indicating that cholinergic neurons are selectively lost in patients with
Alzheimer's disease (AD) and senile dementia of the Alzheimer type (SDAT) suggest that …

The status of cholinergic receptors in dementia is related to the question of potential
cholinergic therapy. Whilst muscarinic receptor binding is generally reported to be normal or …

The neurochemical pathology of Alzheimer's disease (AD) has been consistently shown to
involve cholinergic degeneration in the cerebral cortex. This together with evidence from …

Alzheimer's disease (AD) is characterized by degeneration of neurons in several
neurotransmitter-specific systems (Price et al., in press; Whitehouse et al., in press b) …

In Alzheimer's disease (AD) and Parkinson's disease (PD), dysfunction in the basal forebrain
cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers …

Abstract Changes in the cholinergic, serotonergic, noradrenergic, dopaminergic, GABAergic
and somatostatinergic neurons were investigated to determine their roles in Alzheimer's …

Loss of cortical nicotinic acetylcholine receptors with high affinity for agonists (20–50%) in
patients with Alzheimer's disease is a common finding. Recent immunochemical analyses …

Impairment of cholinergic transmission and decreased numbers of nicotinic binding sites are
well‐known features accompanying the cognitive dysfunction seen in Alzheimer's disease …

Nicotine promotes transmitter release in the brain by a direct action on presynaptic
terminals. Pharmacological evidence confirms that this action is mediated by nicotinic …

Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four
histologically normal controls and five histopathologically verified cases of Alzheimer‐type …