A qualitative and quantitative immunohistochemical study of cholinergic systems in the
human hippocampal formation was performed with an antibody against choline …

Over the last 30 years, it has become well-recognized that drugs blocking the muscarinic
subtype of acetylcholine (ACh) receptors in the brain have selective and reproducible effects …

Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have
been closely related to cholinergic deficits. We have compared different markers of …

In the late 1970s a profound and consistent loss of choline acetyl transferase (CT), a
presynaptic marker for acetylcholine (ACh), was observed in the brains of Alzheimer disease …

Cerebral cortical cholinergic deficits, represented by a decrease in choline acetyltransferase
activity, severe losses of nicotinic binding sites as well as cell degeneration in the basal …

Postmortem cerebral neocortical and hippocampal samples were taken from patients who
died with dementia of the Alzheimer type (DAT) and individuals without diagnoses of …

Cholinergic neurons were studied by immunohistochemistry, with an antiserum against
choline acetyltransferase (ChAT), in the basal forebrain (Ch1 to Ch4) of four patients with …

The cellular distribution of muscarinic acetylcholine receptor protein in the frontal cortex of
Alzheimer (AD) patients, age-matched and middle-aged controls was assessed …

The cholinergic enzyme, choline acetyltransferase (CAT) has been estimated in autopsy
brain tissue obtained from elderly, mentally normal and abnormal hospital patients …

Total muscarinic receptor levels, the levels of the subtypes exhibiting high and low affinity for
pirenzepine, and the high‐and low‐affinity agonist states of the receptor were investigated in …