Interest in the role of nicotinic systems in the cognitive disorder of Alzheimer's disease (AD)
increased after the development of the ability to image and map central nervous system …

Cholinergic enzyme activity (choline acetyltransferase, CAT acetylcholinesterase, AChE)
and muscarinic cholinergic receptor density were measured in frontal cortex (Brodmann's …

Approximately 20 years after the formulation of the “cholinergic hypothesis” to explain the
cognitive symptoms of Alzheimer's disease, cholinesterase therapy remains the mainstay of …

Abstract [3 H] Hemicholinium-3 ([3 H] HC-3) binding, as a marker of the presynaptic high-
affinity choline uptake carrier (HACU), and cholinergic muscarinic receptors were measured …

Nicotinic cholinoceptive dysfunction associated with cognitive impairment is a leading
neurochemical feature of Alzheimer's disease. There-fore, nicotinic acetylcholine receptors …

The pathological processes that lead to Alzheimer's disease (AD) begin decades before the
onset of dementia. Brain abnormalities in genetically susceptible individuals have been …

The neurodegenerative diseases are characterized by a progressive process of neuronal
and myelin breakdown resulting in changes in the morphology and function of neurons and …

We have observed dystrophic choline acetyltransferase (ChAT)-positive processes
surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and …

Intellectual deterioration may be observed in the course of Parkinson's disease. Since it had
been reported that central cholinergic systems degenerate in senile dementia and …