Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis

HY Huang, HC Chou, CH Law… - Journal of Cellular …, 2020 - Wiley Online Library
Cancer metastasis is a common cause of failure in cancer therapy. However, over 60% of
oral cancer patients present with advanced stage disease, and the five‐year survival rates of …

Role of PGRMC1 in cell physiology of cervical cancer

CC Shih, HC Chou, YJ Chen, WH Kuo, CH Chan… - Life sciences, 2019 - Elsevier
Aims The most frequent cancers among women worldwide. The mortality of cervical cancer
has declined significantly primarily due to the widespread use of Pap smear tests as a …

Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer

SR Lee, YH Lee, SL Jo, JH Heo, G Kim, GS Lee… - Cell Communication and …, 2021 - Springer
Background Progesterone receptor membrane component 1 (Pgrmc1) is a non-classical
progesterone receptor associated with the development of the mammary gland and …

Identification of PGRMC1 as a Candidate Oncogene for Head and Neck Cancers and Its Involvement in Metabolic Activities

Y Zhao, X Ruan - Frontiers in Bioengineering and Biotechnology, 2020 - frontiersin.org
Progesterone Receptor Membrane Component 1 (PGRMC1/Sigma-2 receptor) is located on
chromosome Xq21 and encodes a haem-containing protein that interacts with epidermal …

[HTML][HTML] Role of IGFBP-2 in oral cancer metastasis

YF Tsai, HC Chou, MH Liou, EC Liao, CT Cheng… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Cancer metastasis is one of most main causes of failure in cancer treatment. Nonetheless,
more than half of oral cancer patients were diagnosed as advanced oral cancer with …

Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling

DA Pedroza, V Rajamanickam, R Subramani… - British journal of …, 2020 - nature.com
Background Increased expression of the progesterone receptor membrane component 1
(PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a …

Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma

S Liu, D Ye, T Wang, W Guo, H Song, Y Liao… - Cancer cell …, 2017 - Springer
Background G protein–coupled receptor family C group 5 member A (GPRC5A), a retinoic
acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of …

Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells

YL Chen, WL Wu, CW Jang, YC Yen, SH Wang… - Oncogene, 2019 - nature.com
In an effort to understand the underlying mechanisms of lymph node metastasis in oral
squamous cell carcinoma (OSCC), through in vivo selection, LN1-1 cells were previously …

[HTML][HTML] PGRMC1 elevation in multiple cancers and essential role in stem cell survival

KK Hampton, R Stewart, D Napier… - Advances in lung …, 2015 - ncbi.nlm.nih.gov
Cancer is one of the leading causes of death in America, and there is an urgent need for
new therapeutic approaches. The progesterone receptor membrane component 1 …

MMP‐9 knockdown inhibits oral squamous cell carcinoma lymph node metastasis in the nude mouse tongue‐xenografted model through the RhoC/Src pathway

P Yin, Y Su, S Chen, J Wen, F Gao… - Analytical Cellular …, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) is one of the most common types of cancers in
developing countries. A major contributor to the high mortality rate of OSCC is the tendency …