Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an
inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under …

Tumors that form as a result of heightened mammalian target of rapamycin (mTOR)
signaling are highly vascularized. This process of angiogenesis is regulated through …

Rapamycin is a clinically approved immunosuppressive agent that has recently shown
promising antitumor activities in human patients. In contrast to many conventional …

Constitutive expression of hypoxia-inducible factor (HIF) has been implicated in several
proliferative disorders. Constitutive expression of HIF1α and HIF2α has been linked to a …

Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response
to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low …

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …

The mammalian target of rapamycin (mTOR) pathway, which is essential for cell
proliferation, is repressed in certain cell types in hypoxia. However, hypoxia-inducible factor …

Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that
enable cells to adapt to reduced O2 availability. Proteins encoded by HIF-1 target genes …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates
adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers …

Abstract Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates genes
involved in adaptation to hypoxia. Expression of HIF-1α was evaluated in rat and human …