Risk assessment of endocrine disrupters: the role of toxicological studies

A Mantovani - Annals of the New York Academy of Sciences, 2006 - Wiley Online Library
Endocrine disrupters (ED) represent a good challenge for experimental toxicology. In order
to deal with several critical points relevant to risk assessment:(a) ED may induce long‐term …

Endocrine disruptors: can biological effects and environmental risks be predicted?

RJ Witorsch - Regulatory Toxicology and Pharmacology, 2002 - Elsevier
A large number of diverse nonsteroidal chemicals, referred to as xenoestrogens, bind to the
estrogen receptor (ER) and evoke biological responses. The activity of most xenoestrogens …

Perspective on health effects of endocrine disruptors with a focus on data gaps

RE FitzGerald - Chemical research in toxicology, 2020 - ACS Publications
Screening for endocrine disrupting properties at the molecular and cellular level is
developing rapidly, but can epidemiology bridge the gap to human health impact? Reviews …

Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system

H Autrup, FA Barile, BJ Blaauboer… - Toxicological …, 2015 - academic.oup.com
The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors',
is highly controversial and includes challenges of the present paradigms used in toxicology …

An evaluation of endocrine modulators: implications for human health

DR Juberg - Ecotoxicology and Environmental Safety, 2000 - Elsevier
The potential health risk of a group of chemicals, popularly known as “endocrine disrupters,”
has generated considerable scientific debate and media attention. The endocrine disrupter …

Human exposures and body burdens of endocrine-disrupting chemicals

AM Calafat, LL Needham - … -disrupting chemicals: from basic research to …, 2007 - Springer
In today's industrial societies, humans may be exposed to a wide variety of environmental
chemicals, including those with potential endocrine-disruptive properties. Although for many …

[HTML][HTML] Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern

R Bars, I Fegert, M Gross, D Lewis, L Weltje… - Regulatory Toxicology …, 2012 - Elsevier
The European regulation on plant protection products (1107/2009)(EC, 2009a), the
revisions to the biocides Directive (COM [2009] 267)(EC, 2009b), and the regulation …

[HTML][HTML] Endocrine disruptors: challenges and future directions in epidemiologic research

V Ho, L Pelland-St-Pierre, S Gravel, MF Bouchard… - Environmental …, 2022 - Elsevier
Public concern about the impact of endocrine disrupting chemicals (EDCs) on both humans
and the environment is growing steadily. Epidemiologic research provides key information …

Uncertainties for endocrine disrupters: our view on progress

GP Daston, JC Cook, RJ Kavlock - Toxicological Sciences, 2003 - academic.oup.com
The hypothesis that hormonally active compounds in the environment—endocrine disrupters—
are having a significant impact on human and ecological health has captured the public's …

[HTML][HTML] Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement

R Solecki, A Kortenkamp, Å Bergman, I Chahoud… - Archives of …, 2017 - Springer
Endocrine disruption is a specific form of toxicity, where natural and/or anthropogenic
chemicals, known as “endocrine disruptors”(EDs), trigger adverse health effects by …