Cardiovascular disease (CVD) has become the leading cause of death globally. Nattokinase
(NK), as a novel thrombolytic agent, has gained more and more attention. However, NK is …

Nattokinase (NK), which has been identified as a potent fibrinolytic protease, has
remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate …

Nattokinase, is an effective fibrinolytic enzyme with the potential for fighting cardiovascular
disease. The aim of study was to investigate the interaction of Tb (III) with nattokinase and …

The present research work describes the downstreaming of nattokinase (NK) produced by
Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of …

Natto, a fermented soybean product, has been consumed as a traditional food in Japan for
thousands of years. Nattokinase (NK), a potent blood-clot dissolving protein used for the …

Nattokinase (NK) is a serine protease of the subtilisin family; as a potent fibrinolytic enzyme,
it is potentially useful for thrombosis therapy. For NK to be applied as an oral medicine for …

Nattokinase is a promising thrombolytic drug due to its powerful fibrinolytic effect and few
side effects. However, the low fibrinolytic activity and stability of nattokinase have limited its …

Heparin is a widely used anticoagulant in hemodialysis (HD) for patients with chronic kidney
disease (CKD); however, it entails the risk of thrombus formation due to heparin-induced …

Background Nattokinase (NK) is a serine protease enzyme of the subtilisin family. It exhibits
a strong fibrinolytic activity. The fibrinolytic enzymes from Bacillus sp. have attracted interest …

Our aim was to determine the quantitative effects of a single-dose of Nattokinase (NK)
administration on coagulation/fibrinolysis parameters comprehensively in healthy male …