Grafting autoimmune-diabetic recipients with allogeneic islets, graft rejection and disease
recurrence as major problems of reaching indefinite survival and tolerance induction have to …

We studied the effects of anti-CD4 treatment of diabetic ACI rats on the induction oftolerance
to allogeneic (Lewis) islet allografts. When given as a 4-day treatment regimen, OX38, a …

Background. T-cell activation and the subsequent induction of effector functions require not
only the recognition of antigen peptides bound to MHC molecules by T-cell receptor (TCR) …

Background. Successful islet transplantation in type 1 diabetes requires tolerance induction
of both allo-and autoreactive T-cell responses. Monoclonal antibodies targeting the CD4 …

Pancreatic islets obtained from the congenic LEW. 1BB/OK rat strain (MHC identical,
different in genetic background from BB/OK rats) were grated into diabetic BB/OK rats. The …

MATERIALS AND METHODS All rat strains used were bred in the Animal Laboratories of the
Institute of Diabetes “Gerhardt Katsch,” Karlsburg, Germany. Diabetic BBiOK rats (RT. l”, n …

CD4+ T cells play a major role in xenogeneic islet graft rejection and recurrence of
autoimmune diabetes after islet transplantation. CD4 molecule is required as a co-receptor …

Type 1 diabetes is an autoimmune disease characterized by T cell–mediated destruction of
pancreatic islet beta cells. Pancreatic islet transplantation with long‐term …

EFFECT OF THERAPY WITH NON-DEPLETING ANTI-CD4 MONOCLONAL ANT... :
Transplantation EFFECT OF THERAPY WITH NON-DEPLETING ANTI-CD4 MONOCLONAL …

Diabetes in NOD mice is an autoimmune disease similar to Type I diabetes in humans. Prior
to hypoglycemia, changes in the islet infiltrate led to autoreactive T cell activation and …