Alzheimer's disease (AD) is characterized by accumulation of β‐amyloid plaques (AP) and
neurofibrillary tangles (NFT) in the cortex, together with synaptic loss and amyloid …

Cathepsin D (CTSD), a protease detectable in different cell types whose primary function is
to degrade proteins by bulk proteolysis in lysosomes, has been suggested to be involved in …

Proteolysis catalyzed by the major lysosomal aspartyl protease cathepsin-D (CTSD)
appears to be of pivotal importance for proteostasis within the central nervous system and in …

In Alzheimer's disease brains, more than 90% of pyramidal neurons in lamina V and 70% in
lamina III displayed 2-to 5-fold elevated levels of cathepsin D (Cat D) mRNA by in situ …

Alzheimer's disease (AD) is a fatal progressive neurodegenerative disorder characterized by
loss in memory, cognition, and executive function and activities of daily living. AD …

Several neurodegenerative diseases are characterized by the accumulation of ubiquitin-
positive protein aggregates in affected brain regions [1]. These misfolded/aberrant proteins …

Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain
disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal …

Although Alzheimer's disease (AD) is the most common neurodegenerative disease, there
are still no drugs available to treat or prevent AD effectively. Here, we examined changes in …

In familial neurodegenerative disorders, protein aggregates form continuously because of
genetic mutations that drive the synthesis of truncated or unfolded proteins. The oxidative …

Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the
amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been …