Mismatch repair-deficient (MMRD) brain tumors are rare among primary brain tumors and
can be induced by germline or sporadic mutations. Here, we report 13 MMRD-associated (9 …

Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis
compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known …

Background Glioblastoma (GBM) is the most common and malignant gliomas of adults and
recur, resulting in death, despite surgery, radiotherapy, and temozolomide-based …

Background Malignant brain tumors (BT) are among the cancers most frequently associated
with constitutional mismatch repair deficiency (CMMRD), a rare childhood cancer …

Background Constitutional mismatch repair deficiency (CMMRD) results from a biallelic
germline pathogenic variant in a mismatch repair (MMR) gene. The most common CMMRD …

A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such
tumors are resistant to alkylating chemotherapies, they may also express more mutant …

About 15% of sporadic gastrointestinal and endometrial tumors show the microsatellite
instability (MSI) phenotype because of loss of DNA mismatch repair (MMR) function. The …

Abstract Objectives: Methylated O6-methylguanin-DNA-methytransferase (MGMT) promoter
methylation is associated with survival in patients with glioblastoma. Current evidence …

Background and purpose Brain tumors represent a rare and relatively uncharacterized
tumor type in Lynch syndrome. Methods The national Danish Hereditary Nonpolyposis …

Background: Tumours are responsive to temozolomide (TMZ) if they are deficient in O 6-
methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient …