Pre-clinical and clinical development of the first placental malaria vaccine

C Pehrson, A Salanti, TG Theander… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Malaria during pregnancy is a massive health problem in endemic areas.
Placental malaria infections caused by Plasmodium falciparum are responsible for up to one …

[HTML][HTML] Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

A Chêne, S Houard, MA Nielsen, S Hundt, F D'Alessio… - 2016 - Springer
Placental malaria caused by Plasmodium falciparum infection constitutes a major health
problem manifesting as severe disease and anaemia in the mother, impaired fetal …

[HTML][HTML] Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

Maternal immunization and malaria in pregnancy

PE Duffy - Vaccine, 2003 - Elsevier
Malaria in pregnancy is a major cause of poor outcomes for both mother and fetus, and
malaria-induced low birth weight (LBW) may kill nearly 400,000 African infants each year …

Malaria vaccine trials in pregnant women: an imperative without precedent

SA Healy, M Fried, T Richie, K Bok, M Little, A August… - Vaccine, 2019 - Elsevier
Pregnant women are highly susceptible to Plasmodium falciparum malaria, leading to
substantial maternal, perinatal, and infant mortality. While malaria vaccine development has …

Development of vaccines to prevent malaria in pregnant women: WHO MALVAC meeting report

C Menendez, VS Moorthy, Z Reed, A Bardaji… - Expert review of …, 2011 - Taylor & Francis
The major public health consequences of malaria in pregnancy have long been
acknowledged. However, further information is still required for development and …

Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria

M Fried, M Avril, R Chaturvedi, P Fernandez… - Infection and …, 2013 - Am Soc Microbiol
Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to
the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women …

[HTML][HTML] Comparison of functional assays used in the clinical development of a placental malaria vaccine

C Pehrson, KK Heno, Y Adams, M Resende… - Vaccine, 2017 - Elsevier
Background Malaria in pregnancy is associated with significant morbidity in pregnant
women and their offspring. Plasmodium falciparum infected erythrocytes (IE) express …

Developing vaccines to prevent malaria in pregnant women

N Tuikue-Ndam, P Deloron - Expert opinion on biological therapy, 2015 - Taylor & Francis
Introduction: Placental malaria (PM) is a major public health problem that constitutes a
significant health concern for the mother, and especially for the developing fetus and …

First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

B Mordmüller, M Sulyok, D Egger-Adam… - Clinical Infectious …, 2019 - academic.oup.com
Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …