HIV persistence in the CNS despite antiretroviral therapy may cause neurological disorders
and poses a critical challenge for HIV cure. Understanding the pathobiology of HIV-infected …

Background HIV associated neurocognitive disorders cause significant morbidity and
mortality despite the advent of highly active antiretroviral therapy. A deeper understanding of …

Microglia cells are the major reservoir of HIV-1 (HIV) within the CNS. However, current
models using transformed cell lines are not representative of primary microglia and fetal …

Background HIV-1-infected and immune competent brain mononuclear phagocytes (MP;
macrophages and microglia) secrete cellular and viral toxins that affect neuronal damage …

Cognitive impairment in individuals infected with HIV is highly prevalent despite life-long
antiretroviral therapy. A growing line of evidence suggests that the human brain serves as a …

HIV-1 associated neurocognitive disorder (HAND) is characterized by neuroinflammation
and glial activation that, together with the release of viral proteins, trigger a pathogenic …

The achievement of an HIV cure is dependent on the eradication or permanent silencing of
HIV-latent viral reservoirs, including the understudied central nervous system (CNS) …

Parenchymal microglia are targets of HIV infection. We, as well as others, have used in vitro
microglia culture systems to study the tropism and replication of HIV. Characterization of …

The persistence of HIV-1 viral reservoirs in the brain, despite treatment with combination
antiretroviral therapy (cART), remains a critical roadblock for the development of a novel …

Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders
(HAND) are found in nearly one-third of patients. Using a cellular co-culture system …