Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

E Teng, K Taylor, T Bilousova, D Weiland, T Pham… - Neurobiology of …, 2015 - Elsevier
Increased dietary consumption of docosahexaenoic acid (DHA) is associated with
decreased risk for Alzheimer's disease (AD). These effects have been postulated to arise …

Docosahexaenoic acid stimulates non‐amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease

C Sahlin, FE Pettersson, LNG Nilsson… - European Journal of …, 2007 - Wiley Online Library
Epidemiological studies suggest that a high intake of polyunsaturated fatty acids, such as
docosahexaenoic acid (DHA), is associated with a reduced risk of Alzheimer's disease …

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model

GP Lim, F Calon, T Morihara, F Yang… - Journal of …, 2005 - Soc Neuroscience
Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated
fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of …

Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model

GM Cole, SA Frautschy - Nutrition and health, 2006 - journals.sagepub.com
Genetic data argues that Alzheimer's disease (AD) can be initiated by aggregates of a 42
amino acid beta amyloid peptide (Aβ42). The Aβ aggregates, notably small oligomer …

Endogenous docosahexaenoic acid (dha) prevents aβ1–42 oligomer-induced neuronal injury

Y Tan, H Ren, Z Shi, X Yao, C He, JX Kang… - Molecular …, 2016 - Springer
The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) or n-3 fatty acid
has been associated with reduced risk of Alzheimer's disease (AD) in epidemiological …

Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-β and tau pathology via a mechanism involving presenilin 1 levels

KN Green, H Martinez-Coria, H Khashwji… - Journal of …, 2007 - Soc Neuroscience
The underlying cause of sporadic Alzheimer disease (AD) is unknown, but a number of
environmental and genetic factors are likely to be involved. One environmental factor that is …

[HTML][HTML] DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?

Z Amtul, M Keet, L Wang, P Merrifield, D Westaway… - PLoS …, 2011 - journals.plos.org
Numerous reports have documented the beneficial effects of dietary docosahexaenoic acid
(DHA) on beta-amyloid production and Alzheimer's disease (AD). However, none of these …

Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid‐β oligomers

S Florent, C Malaplate‐Armand… - Journal of …, 2006 - Wiley Online Library
A growing body of evidence supports the notion that soluble oligomers of amyloid‐β (Aβ)
peptide interact with the neuronal plasma membrane, leading to cell injury and inducing …

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

JF Quinn, R Raman, RG Thomas, K Yurko-Mauro… - Jama, 2010 - jamanetwork.com
Context Docosahexaenoic acid (DHA) is the most abundant long-chain polyunsaturated fatty
acid in the brain. Epidemiological studies suggest that consumption of DHA is associated …

Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies

F Calon, G Cole - Prostaglandins, Leukotrienes and Essential Fatty Acids, 2007 - Elsevier
Studies in animals clearly show that oral intake of docosahexaenoic acid (DHA) can alter
brain DHA concentrations and thereby modify brain functions. This provides us with an …