The mysteries of capsaicin-sensitive afferents

MJM Fischer, CI Ciotu, A Szallasi - Frontiers in Physiology, 2020 - frontiersin.org
A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …

Capsaicin and sensory neurones: a historical perspective

J Szolcsányi - Capsaicin as a Therapeutic Molecule, 2014 - Springer
Capsaicin, the pungent ingredient of red pepper has become not only a “hot” topic in
neuroscience but its new target-related unique actions have opened the door for the drug …

A single TRPV1 amino acid controls species sensitivity to capsaicin

Y Chu, BE Cohen, H Chuang - Scientific reports, 2020 - nature.com
Chili peppers produce capsaicin (a vanilloid) that activates the transient receptor potential
cation channel subfamily V member 1 (TRPV1) on sensory neurons to alter their membrane …

TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia

P Holzer - European journal of pharmacology, 2004 - Elsevier
Capsaicin, the pungent ingredient in red pepper, has been used since ancient times as a
spice, despite the burning sensation associated with its intake. More than 50 years ago …

Capsaicin, nociception and pain

B Frias, A Merighi - Molecules, 2016 - mdpi.com
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate

T Iida, T Moriyama, K Kobata, A Morita, N Murayama… - …, 2003 - Elsevier
Capsiate is a capsaicin-like ingredient of a non-pungent cultivar of red pepper, CH-19
sweet. To elucidate the mechanisms underlying the non-pungency of capsiate, we …

[HTML][HTML] Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain

V Arora, JN Campbell, MK Chung - Pharmacology & therapeutics, 2021 - Elsevier
Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Capsaicin receptor: TRPV1 a promiscuous TRP channel

SC Pingle, JA Matta, GP Ahern - Transient Receptor Potential (TRP) …, 2007 - Springer
TRPV1, the archetypal member of the vanilloid TRP family, was initially identified as the
receptor for capsaicin, the pungent ingredient in hot chili peppers. The receptor has a …

Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions

YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

Ca2+/Calmodulin Modulates TRPV1 Activation by Capsaicin

T Rosenbaum, A Gordon-Shaag, M Munari… - The Journal of general …, 2004 - rupress.org
TRPV1 ion channels mediate the response to painful heat, extracellular acidosis, and
capsaicin, the pungent extract from plants in the Capsicum family (hot chili …