Invasive aspergillosis has been studied in laboratory by the means of plethora of distinct
animal models. They were developed to address pathophysiology, therapy, diagnosis, or …

Aspergillosis is an airborne fungal disease caused by Aspergillus spp., a group of
ubiquitous molds. This disease causes high morbidity and mortality in both humans and …

Highlights•Invasive aspergillosis is a life-threatening infection in immunocompromised
patients.•There is a clear need for new antifungals against invasive aspergillosis.•Evaluation …

The diagnosis of invasive aspergillosis remains very difficult, coupled with limited treatment
options. Animal models have been utilized to evaluate both the diagnosis and treatment of …

The growing importance of infectious caused by Aspergillus species during the last decade
has created a need for practical and reproducible animal models of invasive aspergillosis …

The attempt to establish vaccination strategies against infections caused by Aspergillus
fumigatus seems to be questionable. Invasive aspergilloses are opportunistic diseases of …

Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological
niches. Almost 200 species of aspergilli have been identified, less than 20 of which are …

Conidia of Aspergillus fumigatus are inhaled by humans on daily basis. As a consequence,
these conidia can cause infections that differ in severity ranging from allergic …

Animal models of invasive aspergillosis have been used for virulence studies and antifungal
efficacy evaluations but results have been inconsistent. In an attempt to reproduce human …

Disease manifestations with Aspergillus spp. are very diverse and dependent on interaction
between the fungus and the host. Invasive aspergillosis (IA) is the most severe form of …