The neuropathic pain: An overview of the current treatment and future therapeutic approaches

E Cavalli, S Mammana, F Nicoletti… - International journal …, 2019 - journals.sagepub.com
Neuropathic pain is characterized by abnormal hypersensitivity to stimuli (hyperalgesia) and
nociceptive responses to non-noxious stimuli (allodynia). The conditions and the …

[HTML][HTML] On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review

S Fakhri, F Abbaszadeh, M Jorjani - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

[HTML][HTML] Bioinformatics analysis identifies p53 as a candidate prognostic biomarker for neuropathic pain

Y Gao, N Sun, L Wang, Y Wu, L Ma, J Hong… - Frontiers in …, 2018 - frontiersin.org
Neuropathic pain (NP) is a type of chronic pain that is different from the common type of
pain. The mechanisms of NP are still poorly understood. Exploring the key genes and …

Systematic analysis of critical genes and pathways identified a signature of neuropathic pain after spinal cord injury

Z Li, H Bai, R Zhang, B Chen, J Wang… - European Journal of …, 2022 - Wiley Online Library
Spinal cord injury (SCI) damages sensory systems, producing chronic neuropathic pain that
is resistant to medical treatment. The specific mechanisms underlying SCI‐induced …

Chemokines in neuron–glial cell interaction and pathogenesis of neuropathic pain

ZJ Zhang, BC Jiang, YJ Gao - Cellular and Molecular Life Sciences, 2017 - Springer
Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …

Neuropathic pain

J Borzan, RA Meyer - Encyclopedia of Neuroscience, 2009 - pure.johnshopkins.edu
Certain diseases, chemotherapy, or nerve traumas can lead to pathology in the peripheral or
central nervous system that causes chronic neuropathic pain. Peripheral and central …

[HTML][HTML] Mediators of inflammation as targets for chronic pain treatment

M Lipnik-Stangelj - Mediators of inflammation, 2013 - ncbi.nlm.nih.gov
Treatment of chronic pain remains an unresolved problem in human medicine which greatly
impairs quality of life and prolongs treatment. Solving this problem is difficult due to a …

[HTML][HTML] Novel therapies for the treatment of neuropathic pain: potential and pitfalls

P Shinu, MA Morsy, AB Nair, AKA Mouslem… - Journal of Clinical …, 2022 - mdpi.com
Neuropathic pain affects more than one million people across the globe. The quality of life of
people suffering from neuropathic pain has been considerably declining due to the …

Pathophysiological mechanisms of neuropathic pain

A Truini, G Cruccu - Neurological Sciences, 2006 - Springer
It is largely acknowledged that multiple and complex pathophysiological mechanisms may
be at play in neuropathic pain. This short review summarises the current understanding of …

From the gender gap to neuroactive steroids: exploring multiple cases to further understand neuropathic pain

S Marinelli, R Coccurello - International Journal of Molecular Sciences, 2023 - mdpi.com
Neuropathic pain (NeuP) is still an intractable form of highly debilitating chronic pain,
resulting from a lesion or disease of the somatosensory nervous system [1]. It is well …