AIM To explore the effect of ciliary neurotrophic factor (CNTF) on retinal ganglion cell (RGC)-
5 induced by hydrogen peroxide (H 2 O 2). METHODS After cell adherence, RGC-5 culture …

Ciliary neurotrophic factor (CNTF) acts in several processes in the vertebrate retina,
including neuroprotection of photoreceptors in the stressed adult retina and regulation of …

Objective To investigate the efficacy of subretinal transplantation of CNTF gene transfected
fibroblasts for preventing photoreceptor degeneration in RCS. Methods The human fetal …

Objective Ciliary neurotrophic factor (CNTF) has been evaluated as a candidate therapeutic
agent for diabetes and its neural complications. However, its role in diabetic retinopathy has …

Intravitreal neovascular diseases are a major cause of blindness worldwide. It remains
unclear why neovessels in many retinal diseases spread into the physiologically …

purpose. To examine whether ciliary neurotrophic factor (CNTF) has a chemotactic effect on
macrophages and whether macrophages are involved in CNTF-induced retinal ganglion cell …

Purpose: The CXC receptor 4 (CXCR4) is required for various physiologic and pathologic
processes in the eye, including stem cell trafficking, neuronal development, immune …

ABSTRACT Purpose/Aim Abnormal activation of signaling pathways related to
angiogenesis, inflammation, and oxidative stress has been implicated in the …

Retinal neovascularization (RNV) is a common pathology of blinding proliferative
retinopathies. The current treatments to RNV, however, are hindered by limited efficacy, side …

Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for
neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes …