Cancer is currently the second leading cause of death worldwide as over 500 thousand
patients will succumb to the disease. The development of immune-and targeted therapies …

The appropriate coordination between epigenetic regulators is essential for spatial and
temporal regulation of gene expression and maintenance of cell identity. Cancer is a …

Immunotherapy is rapidly emerging as a promising approach against cancer. In the last
decade, various immunological mechanisms have been targeted to induce an increase in …

Epigenetic regulation refers to the alteration of gene expression independent of changes in
DNA sequence. It involves chemical modifications such as DNA methylation, histone …

Background Epigenetic mechanisms regulate chromatin accessibility patterns that govern
interaction of transcription machinery with genes and their cis-regulatory elements …

DNA sequence has little bearing on the dynamic and heritable changes to the genome that
occur in epigenetics. Both genetic and epigenetic alterations influence the development of …

Recently, immunotherapeutic approaches have shown impressive responses in a subset of
cancer patients. However, the rate of success is low and a large percentage of treated …

Cancer chemotherapeutic drugs have greatly advanced our ability to successfully treat a
variety of human malignancies. The different forms of stress produced by these agents in …

Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …

Epigenetic dysregulation is a common feature of most cancers, often occurring directly
through alteration of epigenetic machinery. Over the last several years, a new generation of …