Background A 55-year-old woman was followed over a 13-year period as part of a
longitudinal study of people at risk for familial dementia. She was a member of a family with …

Background In this paper, we describe the clinical and neuropathological findings of nine
members of the Belgian progranulin gene (GRN) founder family. In this family, the loss-of …

Objective Familial autosomal dominant frontotemporal dementia with ubiquitin‐positive, tau‐
negative inclusions in the brain linked to 17q21‐22 recently has been reported to carry null …

Two hundred and twenty-three consecutive patients fulfilling clinical diagnostic criteria for
frontotemporal lobar degeneration (FTLD), and 259 patients with motor neuron disease …

Background: Frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions
(FTLD-TDP) may appear as sporadic (sFTLD-TDP) or linked to mutations in various genes …

The progranulin gene (PGRN) encodes a pleiotropic molecule with anti-inflammatory
actions and neuronal protective effects. Accordingly, PGRN-deficient mice have been …

Mutations in the progranulin (PGRN) gene have been recently demonstrated as a cause of
frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal inclusion …

Background: Frontotemporal dementia (FTD) is the second most common type of presenile
dementia and can be distinguished into various clinical variants. The identification of MAPT …

Background In recent years, a benign variant of frontotemporal lobar degeneration (FTLD)
has been recognized, with a particularly slow progression of cognitive deficits and scarce …

Mutations in the progranulin (PGRN) gene have recently been identified in families with
frontotemporal lobar degeneration and ubiquitin-positive brain inclusions linked to …