Purpose Many women with an elevated risk of hereditary breast and ovarian cancer have
previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a …

PURPOSE: Data from the Breast Cancer Linkage Consortium suggest that the proportion of
familial breast and ovarian cancers linked to BRCA1 or BRCA2 may be as high as 98 …

BACKGROUND: In women at increased risk for breast and ovarian cancer, the identification
of a mutation in breast cancer gene 1 (BRCA1) and BRCA2 has important implications for …

The detection of deleterious germline mutations in BRCA1 and BRCA2 considerably
influences the clinical management of healthy and diseased carriers. Therefore, the …

Purpose Recent advances in DNA sequencing have led to the development of breast cancer
susceptibility gene panels for germline genetic testing of patients. We assessed the …

OBJECTIVE: To correlate mutations in BRCA1 and BRCA2 with family history of breast
cancer in a first‐degree relative for women diagnosed with breast cancer before age 45 who …

Purpose Women with germline BRCA1 and BRCA2 mutations have five-to 20-fold increased
risks of developing breast and ovarian cancer. A recent study claimed that women testing …

Risk assessment coupled with genetic counseling and testing for the cancer predisposition
genes BRCA1 and BRCA2 (BRCA1/2) has become an integral element of comprehensive …

Purpose Mutations in the BRCA1 and BRCA2 genes are responsible for approximately 2%
of breast cancers by age 70 years. Professional and governmental groups recommend …

Background Familial breast cancer accounts for 20–30% of all breast cancer cases.
Mutations in the BRCA1 and BRCA2 genes account for the majority of high risk families with …