[HTML][HTML] Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis

M Knipper, P Van Dijk, I Nunes, L Rüttiger… - Progress in …, 2013 - Elsevier
The prevalence of hearing problems in the Western world has, due to aging of the
population, doubled over the past 30 years. Thereby, noise-induced hearing loss is an …

The relationship of tinnitus, hyperacusis, and hearing loss

JJ Nelson, K Chen - Ear, nose & throat journal, 2004 - journals.sagepub.com
The triad of tinnitus, hyperacusis, and hearing loss remains an often-underdiagnosed
combination of symptoms that causes physical, mental, and emotional distress for millions of …

Tinnitus, diminished sound-level tolerance, and elevated auditory activity in humans with clinically normal hearing sensitivity

JW Gu, CF Halpin, EC Nam… - Journal of …, 2010 - journals.physiology.org
Phantom sensations and sensory hypersensitivity are disordered perceptions that
characterize a variety of intractable conditions involving the somatosensory, visual, and …

Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus

W Singer, A Zuccotti, M Jaumann, SC Lee… - Molecular …, 2013 - Springer
Increasing evidence shows that hearing loss is a risk factor for tinnitus and hyperacusis.
Although both often coincide, a causal relationship between tinnitus and hyperacusis has …

[HTML][HTML] Tinnitus: does gain explain?

W Sedley - Neuroscience, 2019 - Elsevier
Many, or most, tinnitus models rely on increased central gain in the auditory pathway as all
or part of the explanation, in that central auditory neurones deprived of their usual sensory …

The auditory sensitivity is increased in tinnitus ears

S Hébert, P Fournier, A Noreña - Journal of Neuroscience, 2013 - Soc Neuroscience
Increased auditory sensitivity, also called hyperacusis, is a pervasive complaint of people
with tinnitus. The high prevalence of hyperacusis in tinnitus subjects suggests that both …

Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms

MC Liberman, SG Kujawa - Hearing research, 2017 - Elsevier
Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …

Tinnitus: models and mechanisms

JA Kaltenbach - Hearing research, 2011 - Elsevier
Over the past decade, there has been a burgeoning of scientific interest in the
neurobiological origins of tinnitus. During this period, numerous behavioral and …

The role of central nervous system plasticity in tinnitus

JC Saunders - Journal of communication disorders, 2007 - Elsevier
Tinnitus is a vexing disorder of hearing characterized by sound sensations originating in the
head without any external stimulation. The specific etiology of these sensations is uncertain …

Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss

SG Kujawa, MC Liberman - Hearing research, 2015 - Elsevier
The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our recent work …