Modulating phosphate consumption, a novel therapeutic approach for the control of cancer cell proliferation and tumorigenesis
JL Arnst, GR Beck Jr - Biochemical pharmacology, 2021 - Elsevier
Phosphorus, often in the form of inorganic phosphate (Pi), is critical to cellular function on
many levels; it is required as an integral component of kinase signaling, in the formation and …
many levels; it is required as an integral component of kinase signaling, in the formation and …
Investigating the role of inorganic phosphate in tumor metabolism and metastasis
CP Ramirez, D Fiedler - Cancer & Metabolism, 2014 - Springer
Background Altered cell metabolism is regarded as a hallmark of cancer with numerous
studies highlighting glucose and glutamine as critical nutrients for tumor proliferation …
studies highlighting glucose and glutamine as critical nutrients for tumor proliferation …
Phosphate toxicity and tumorigenesis
RB Brown, MS Razzaque - Biochimica et Biophysica Acta (BBA)-Reviews …, 2018 - Elsevier
In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …
[HTML][HTML] Inorganic phosphate in the development and treatment of cancer: A Janus Bifrons?
L Sapio, S Naviglio - World journal of clinical oncology, 2015 - ncbi.nlm.nih.gov
Inorganic phosphate (Pi) is an essential nutrient to living organisms. It is required as a
component of the energy metabolism, kinase/phosphatase signaling and in the formation …
component of the energy metabolism, kinase/phosphatase signaling and in the formation …
Cancer Cachexia and Dysregulated Phosphate Metabolism: Insights from Mutant p53 and Mutant Klotho Mouse Models
RB Brown - Metabolites, 2022 - mdpi.com
The present perspective article proposes that cachexia, muscle wasting in cancer, is
mediated by dysregulated phosphate metabolism and phosphate toxicity that can damage …
mediated by dysregulated phosphate metabolism and phosphate toxicity that can damage …
High inorganic phosphate intake promotes tumorigenesis at early stages in a mouse model of lung cancer
Inorganic phosphate (Pi) is required by all living organisms for the development of organs
such as bone, muscle, brain, and lungs, regulating the expression of several critical genes …
such as bone, muscle, brain, and lungs, regulating the expression of several critical genes …
Inorganic phosphate as a signaling molecule: a potential strategy in osteosarcoma treatment.
A Spina, L Sorvillo, A Esposito, A Borgia… - Current …, 2013 - europepmc.org
Inorganic phosphate (Pi) is an essential nutrient to living organisms. It plays a key role in
diverse biological processes, including osteoblast differentiation and skeletal mineralization …
diverse biological processes, including osteoblast differentiation and skeletal mineralization …
Interstitial inorganic phosphate as a tumor microenvironment marker for tumor progression
Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters
such as oxygen (p O2), extracellular acidosis (pHe), and concentration of interstitial …
such as oxygen (p O2), extracellular acidosis (pHe), and concentration of interstitial …
Spontaneous Tumor Regression and Reversion: Insights and Associations with Reduced Dietary Phosphate
RB Brown - Cancers, 2024 - mdpi.com
Simple Summary In spontaneous tumor regression, tumors shrink and disappear without
conventional treatments. This phenomenon challenges the view that cancer is an …
conventional treatments. This phenomenon challenges the view that cancer is an …
Regulation of the pentose phosphate pathway in cancer
Energy metabolism is significantly reprogrammed in many human cancers, and these
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …