The prediction of protein three-dimensional structure from amino acid sequence has been a
grand challenge problem in computational biophysics for decades, owing to its intrinsic …

In recent years, there has been significant progress in the ability to predict the three-
dimensional structure of proteins from their amino acid sequence. Progress has been due to …

The field of computational biology has been revolutionized by recent advances in genomics.
The completion of a number of genome projects, including that of the human genome, has …

While most textbooks on bioinformatics focus on genetic algorithms and treat protein
structure prediction only superficially, this course book assumes a novel and unique focus …

Computationally predicted three-dimensional structure of protein molecules has
demonstrated the usefulness in many areas of biomedicine, ranging from approximate …

Protein structures have proven to be a crucial piece of information for biomedical research.
Of the millions of currently sequenced proteins only a small fraction is experimentally solved …

Protein structures are essential in modern biology yet experimental methods are far from
being able to catch up with the rapid increase in available genomic data. Computational …

Computational structure-based protein design programs are becoming an increasingly
important tool in molecular biology. These programs compute protein sequences that are …

The function of proteins can often be inferred from their three-dimensional structures.
Experimental structural biologists spent decades studying these structures, but the …

Protein structure prediction is a way to bridge the sequence-structure gap, one of the main
challenges in computational biology and chemistry. Predicting any protein's accurate …